An Invitation

Welcome message from President of the Joint Meeting

Emerging concerns on functional gastrointestinal disorder research promoted to form academic societies on such field. In Japan, we had two main streams for such interests; motility societies and GI psychosomatic society. We used to believe they are different area of research. However, recent progress showed they are one of the pathophysiologic spectra of functional GI disorders. We have been trying to unite brother and sister societies in such field, and finally such societies will unite in 2017, Japanese Society of Neurogastroenterology and Motility (JSNM), Group for Functional Dyspepsia Research, Group for Irritable Bowel Syndrome Research, and Japanese Society of Psychosomatic Medicine on Digestive Diseases.

ANMA, Asian Neurogastroenterolgy and Motility Association, is an Asian Society for such field. It is our great pleasure to host the 5th Biennial Congress of the Asian Neurogastroenterology and Motility Association (ANMA) in March, 2017, at Osaka, Japan, as a Joint Meeting with 19th Japanese Society of Neurogastroenterology and Motility. This will be the first meeting where Japanese scholars and Asian Scholars meet together to discuss in Japan under the umbrella topic of neurogastroenterology and motility.

We welcome every scholar from the world, especially from Asia.

I, personally, believe that Asian perspectives on neurogastroenterology might be somewhat different from the Western perspectives in some details. Those will be one of the interests to discuss with ANMA and JSNM members.

Besides the academic meeting, our venue of the meeting will be convenient for pre- and post-congress excursions, and the time of late March will be a time for cherry blossoms which will be one of the good reason to travel to Japan at this time.

We wait to see you in Osaka, Japan.

Michio Hongo, MD, PhD, AGAF

President of the Joint Meeting

(Tohoku University, Kurokawa General Hospital)

Welcome message from Congress Governor of the Joint Meeting

It is our great pleasure to have the 19th Annual Meeting of Japanese Society of Neurogastroenterology and Motility (JSNM) and Biennial Congress of the Neurogastroenterology and Motility Association(ANMA) in Osaka International Convention Center, Osaka, Japan on March 23-25,2017. Professor Hiroto Miwa is the president of the 5th ANMA congress and professor Fukudo Shin is the president of 19th JSNM.

Neurogastroenterology is important area and hopeful in whole science. Young talented, scientists should join this meeting. Clinical targets of neurogastroenterology are functional dyspepsia, irritable bowel syndrome, functional constipation, H.pylori―  related disease, gastroesophageal reflux disease etc.
These diseases are, highly ,disturbing quality of life of the patients and induce real social problems.

However, recently, great advances in neurogastroenterology have developed. There are new development of genome analyses, proteome, metabolome, microbiome. Researchers of neurogastroenterogy can use these modalities.

Also the developments of equipments concerning patient condition are excellent.
Positron emission tomography, functional magnetic resonance imaging(MRI), vicerosensory evoked potential, repetitive transcranial magnetic stimulation, are used to study these disorders.

Concerning to MRI, functional MRI based on blood oxygen level dependent effect, arterial spin labeling, diffusion tensor imaging, votex-based morphometry and connectivity analyses with dynamic causal modeling are in progress.
As GI motility, high resolution manometry with impedance measurement 、intraluminal pH monitoring in each GI segment and 13C breath testing (gastric emptying test et al ) also have been developed. Furthermore, cine MRI is applied to evaluate GI motility non-invasively. Capsule endoscopy is adapted to measure GI transit. Molecular biology of the myenteric plexus, interstitial Cajal smooth muscle cells are developing.

Therapeutic advantage is present in neurogastroentelogy. The good sample are 5-HT3 antagonist “ramosetron”, 5-HT4 agonist mosapride, cholinesterase inhibitor “acotiamide”, chloride channel-2 “lubiprostone”, guanylate cyclase C activator “linaclotide” peripheral opioid agonist “eluxadoline”, antimicrobial “rifaximin”, acid-inhibitor agents ”pariet, esomeprazole and vonoprazan”. It is noteworthy that many drugs were developed in Japan. As well as pharmacological treatments, non-pharmacological treatments are also important. Low fementable oligo-di-monosaccharides and polyols (FODMAP) diet, soluble dietary fiber,  probiotics,  prebiotics,  kampo medicine.

We sincerely hope this congress serves places of clinicians, researchers, and others to meet each other, exchange and share various ideas , knowledge and experiences.
We consider that researchers’ participation is very precious and indispensable for the
success of the congress. Thank you and we hope the scientific exchange of the present knowledge of neurogastroenterology and motility in Osaka.

Tetsuya Mine, M.D, Ph D
Congress Governor of the Joint Meeting
(Professor, Department of Gastrointestinal Medicine, Tokai University)

Welcome message from President of the 5th ANMA Congress

I have been appointed as president of the 5th ANMA Congress, March 23rd through 25th of next year, at the Osaka International Convention Center. As you know, ANMA stands for the Asian Neurogastroenterology and Motility Association. ANMA plays a pivotal role in the study of gastroenterology in Asia, and I’m honored to serve as the conference chairperson. It’s a big responsibility.

ANMA has held a general meeting every two years since it was founded in 2008. The first four were in Korea, China, Malaysia, and India, and this meeting in Japan will be the 5th.  Our field of research is still developing, and we have only a limited number of researchers, but we are seeing increasing demand for better understanding of functional gastrointestinal disorders. Those conditions are the primary targets of our research. This new field is scientifically important, and its medical importance is also well recognized, so I believe that this area of study will advance dramatically in the near future. I expect our association to experience substantial growth, too.

The theme of the upcoming convention is “New Era of Functional GI Disorders.” It will be an opportunity for us to discuss pathophysiology and treatment for functional GI disorders from many different angles. The Rome IV guidelines were just published in the spring of 2016, so we have scheduled a Rome IV symposium during the convention, and several board member of the Rome Committee will be invited to our sessions. We will also invite the ANMA board members and many ANMA members representing different Asian nations to discuss functional GI disorders that are particularly characteristic of Asia, and their treatment.

I want us to make the conference meaningful in scientific ways, and useful in clinical practice as well. This ANMA conference is being held jointly with the 19th meeting of the Japanese Society of Neurogastroenterology and Motility, or JSNM, organized by Shin Fukudo, MD, PhD, Professor of Tohoku University. Dr. Fukudo is a world-renowned researcher in this field. As we grow, we also continue to work toward consolidation. Academic conferences in the field of neurogastroenterology and motility have been consolidated already. And the Functional Dyspepsia Study Group, the IBS Study Group, and the Japanese Society of Psychosomatic Medicine on Digestive Diseases are scheduled to be integrated into the Society of Neurogastroenterology and Motility after the 5th ANMA Congress in 2017.

The 5th ANMA / 19th JSNM Joint Congress will provide Japanese study groups and associations of neurogastroenterology and motility an opportunity to enter into a single new organization that will speak with one voice to the world. So this conference will be a memorable event. For this joint meeting, Dr. Michio Hongo, former president of JSNM, is in charge of general operations as the congress president, and Dr. Tetsuya Mine, president of the Japanese Society of Gastroenterology, will serve as the Congress Governor.  Such eminent members of our academic community make this an “All-Japan” event in both name and reality. And all members of our department are dedicating themselves to make this memorable conference a success.

Osaka International Convention Center in Osaka, the venue for the Congress, is a very popular destination among Asian tourists, and the city is famous for its historical sites such as Osaka Castle, and also for its shopping districts. There is so much to enjoy in this city -- shopping, dining, theater-going -- that no one will be able to do it all. And then there are a wealth of famous sightseeing destinations, such as Kyoto, Nara, and Kobe, all easily accessible from Osaka. So we hope that attendees will enjoy Osaka as much as the convention itself. We plan to make this conference an opportunity for our members from Japan and other Asian countries to present new knowledge and findings to the international community. We hope that a great many researchers will submit proposals for a wide variety of presentations, and that the conference will attract large numbers of attendees from all over Japan and Asia.

We are soliciting volunteers now for our organizing committee, to plan and create programs. I am grateful to the Core Program Committee members for their great contributions in planning and creating programs. A number of pharmaceutical companies have also provided generous financial support, which we greatly appreciate. I would like to express my sincere appreciation to all the people who are making this happen. I truly believe that this will be a landmark conference. It will make a long-term contribution to the future of our profession, and most of all to the wellbeing of our patients.

Hiroto Miwa, MD., PhD.

President of the 5th Biennial Congress of the Asian Neurogastroenterology & Motility Association
(Professor and Chairman, Department of Internal Medicine, Hyogo College of Medicine)

Welcome message from President of the 19th JSNM Meeting

It is our great pleasure to have the 19th Annual Meeting of Japanese Society of Neurogastroenterology and Motility (JSNM) and the 5th Biennial Congress of the Asian Neurogastroenterology and Motility Association (ANMA) in Osaka International Convention Center, Osaka, Japan on March 23-25, 2017.  The main theme of this congress is “New Era of Functional GI Disorders.”  This congress is held aiming at encouraging participants to explore new ideas and seek new possibilities for the development of neurogastroenterology.  Participants are active members of JSNM, those of ANMA, invited speakers from Rome Committee, and others who are interested in this area. 

Professor Hiroto Miwa is the president of the 5th ANMA congress and I am the president of the 19th JSNM.  Because we are Rome IV Committee members together with Professor Hidekazu Suzuki, we set collaborative sessions with Rome Committee and ANMA/JSNM.  Like Olympic games, co-operation of this field through the whole nation is indispensable for a great success of the international congress.  Thus, Professor Michio Hongo as the president of the Joint Meeting and Professor Tetsuya Mine as the Congress Governor of the Joint Meeting manage the meeting. 

Neurogastroenterology is he emerging area not only in medicine but also in whole science.  Therefore, young talented scientists should join this meeting.  Clinical targets of neurogastroenterology are functional GI disorders and GI motility disorders.  Irritable bowel syndrome (IBS), functional dyspepsia (FD), functional constipation, and gastroesophageal reflux disease (GERD) are representative disorders.  They are highly prevalent, greatly disturbing quality of life (QOL) of the patients, and making more economical loss.  Surprising advantage of neurogastroenterology continues day by day.  Because now is the era of genome, proteome, metabolome, microbiome, neuroscience, and regenerative medicine, researchers of neurogastroenterology use these new modalities.  Functional GI disorders are disorders of brain-gut interactions.  Positron emission tomography, functional magnetic resonance imaging (MRI), viscerosensory evoked potential, repetitive transcranial magnetic stimulation are used to study these disorders.  Concerning to MRI, functional MRI based on blood oxygen level dependent effect, arterial spin labelling, diffusion tensor imaging, voxel-based morphometry, and connectivity analyses with dynamic causal modeling are in progress. 

Concerning to GI motility, high resolution manometry with impedance measurement and intraluminal pH monitoring in each GI segment has been developed.  Barostat is used to measure tone of the GI wall and GI sensitivity.  Cine MRI is also applied to evaluate GI motility non-invasively.  Capsule endoscopy is adapted to measure GI transit as well as radiopaque markers.  Molecular biology of the myenteric plexus, interstitial cells of Cajal, smooth muscle cells as well as neural stem cells and enteric glia cells are developing.  Effect of stress greatly influence on GI function via epigenetic mechanism, mucosal immune system, gut microbiota, and mucosal permeability. 

Therapeutic advantage is present in neurogastroenterology.  The good examples are 5-HT3 antagonist ramosetron, 5-HT4 agonist mosapride, cholinesterase inhibitor acotiamide, chloride channel-2 activator lubiprostone, guanylate cyclase C activator linaclotide, peripheral opioid agonist eluxadoline, antimicrobial rifaximin, acid-inhibiting agents esomeprazole and vonoprazan.  It is noteworthy that many nice drugs were developed in Japan or by the Japanese researchers.  Non-pharmacological treatments are also important.  Low fermentable oligo-di-monosaccharides and polyols (FODMAP) diet, soluble dietary fibers, probiotics, prebiotics, kampo medicine, and psychosomatic treatments including psychopharmacological agents, new psychotherapy, and neuromodulatory treatment need randomized controlled trials and meta-analysis. 

We sincerely hope this congress serves as a place for clinicians, researchers, and others to meet each other, exchange and share various ideas, knowledge and experiences.  We consider that active researchers’ participation is very precious and indispensable for the success of the congress.  Thank you and we hope the scientific exchange of the present knowledge of neurogastroenterology and motlity in Osaka.

Shin Fukudo, MD, PhD

President of the 19th Japanese Society of Neurogastroenterology and Motility (JSNM)
(Professor, Department of Behavioral Medicine, Tohoku University Graduate School of Medicine Director, Department of Psychosomatic Medicine, Tohoku University Hospital)

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